ASHG: Statistical Genomics and Beyond GWAS in Complex Disease
The second day of the American Society of Human Genetics Annual Meeting is drawing to a close; here’s a lowdown of what talks I’ve enjoyed today. Remember, follow @lukejostins on Twitter if you want...
View ArticleASHG: Quantifying Relatedness and Active Subjects in Genome Research
Well, the American Society of Human Genetics Annual Meeting is coming to a close for another year. My talk is done and dusted, so I no longer have to lie awake at night worrying that I will forget...
View ArticleHow Many Ancestors Share Our DNA?
This post was written four years ago, using a quick-and-dirty model of recombination to answer the question in the title. Since then a more detailed and rigorously tested model has been developed by...
View ArticleThe Economist Mangles Disease Genetics
The Economist has a rather distressingly bad article by the evolutionary psychologist Geoffrey Miller, about the supposed general failure in human disease genetics over the last 5 years. The thesis is...
View ArticleChristmas Thoughts
A late Merry Christmas, and a marginally early new year to all. A few Christmas-based observations, from various lines of thought that have been knocking around my head over the festive period. Cooking...
View ArticleThe Future of Second Generation Sequencing
Illumina, the major player in high-throughput sequencing these days, have announced the newest version of their second generation sequencing platform, the HiSeq 2000. The machine can produce a lot more...
View ArticleCargo Cult Science and NT Factor®
A recent blog post on Chronic Fatigue Syndrome linked in passing to a ‘treatment’ called Mitochondria Ignite™ with NT Factor®. This product caught my attention as an example of what Richard Feynman...
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David Goldstein Proves Himself Wrong
A recent paper in PLoS Biology by David Goldstein’s group is being seen as another ‘death of GWAS’ moment (again?). I have a lot of issues with this paper, but I will be brief and stick to my main...
View ArticleAGBT: Taking the Statistics out of Statistical Genetics
The second day (or the first day, depending on if you count yesterday’s pre-sessions) of AGBT is nearly done. There has been a lot of things going on today, but I’m only going to cover one; once again,...
View ArticleAGBT: Sequencing Tech Lowdown
Alright, it’s time to address the meat of the matter of AGBT; the state of play of sequencing technology. I’ll go through each of the major companies in turn, and talk about what they’ve brought to the...
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